![]() ![]() The authors advised that, If the patients determined that their symptoms were unacceptably severe, they could discontinue the tablets for that month.ĭefined as the primary endpoint was symptom intensity, calculated as a ratio. ![]() Using a smartphone application, patients reported symptom intensity daily on a scale of 0 (no symptoms) to 100 (worst imaginable symptoms). Participants received four bottles containing atorvastatin at a dose of 20 mg, four bottles containing placebo, and four empty bottles with instructions to use each bottle for a 1-month period according to a random sequence. The goal was to determine whether symptoms would be induced by a statin or placebo. In this case, 60 patients who had previously discontinued statins because of side effects that occurred within 2 weeks after the initiation of treatment were enrolled in a double-blind, three-group, n-of-1 trial. In more severe cases patients could be referred for talking therapies.”īackground information in the report indicates that statins are often discontinued because of side effects, but several blinded trials haven’t shown any excess of symptoms with statins as compared with placebo. One way to help encourage patients to take or stay on their medication is for doctors to talk to their patients about the nocebo effect. These drugs play a significant role in keeping patients who are at risk of cardiovascular disease healthy. “Our findings are significant because they are further evidence that side effects from statins are minimal. Some of the side effects could also be from the typical aches and pains of getting older,” explained first author Frances Wood, MPhil, of Imperial College London. “Our study suggests that the reported side effects of statins are not caused by the statin themselves but by the effect of taking a tablet. Results were published in correspondence to The New England Journal of Medicine. The clinical trial of 60 patients determined that 90% of symptoms experienced by patients on statins also were reported when they took placebo pills. A new placebo study suggests, however, that many of the symptoms also occurred when participants took dummy pills thinking those were cholesterol-lowering drugs. Taking simvastatin in the morning compared with in the evening: Randomised controlled trial.London-Many patients refuse to take statins because of concerns about adverse side effects. Statins: Are these cholesterol-lowering drugs right for you? Retrieved from Class act: Do statins always have to be taken in the evening? Retrieved from Label: Lovastatin - lovastatin tablet.Label: Lipitor- atorvastatin calcium trihydrate tablet, film coated.Label: Fluvastatin- fluvastatin sodium capsule.Label: Altoprev - lovastatin tablet, extended release.You can learn more about how we ensure our content is accurate and current by reading our editorial policy. Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. Sometimes, switching to another statin can help. If you experience side effects, it’s important that you tell your doctor. If you have type 2 diabetes, statins may increase your blood sugar levels. Serious risks include damage to your muscles, kidneys, and liver. Some common side effects include muscle and joint aches, nausea, and headache. Statins can be effective in getting your cholesterol under control, but they come with risks. That includes supplements, over-the-counter medications, and prescription drugs. Statins can also interact with other medications, so tell your doctor about all the drugs you take. If your prescription label doesn’t mention grapefruit juice, be sure to ask your doctor about it. This can increase the risk of muscle breakdown, liver damage, and even kidney failure. Grapefruit juice can cause that statin to stay in your body much longer, and the drug can build up. With some statins, drinking grapefruit juice, or eating grapefruit, is a bad idea. Some substances can interact with statins Once it becomes part of your routine, you’re less likely to forget. Statins work best when taken at the same time each day. If time of day isn’t an issue with your statin, choose the time you’re most likely to remember to take it. Always ask if your statin should be taken with food or at a specific time of day. Your doctor knows your personal medical issues and is your best source for information. Follow directions carefully for maximum effectiveness. That’s why you should thoroughly read the materials that come with your prescription. The most important thing you need to know is that statins aren’t all the same. What you need to know about taking statins ![]()
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